Electronic Resource

(J) Allergic vulvovaginitis: a systematic literature review

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Purpose Despite the vaginal mucosa is able to respond to allergenic stimuli, vaginal allergic responses have been under
investigated in clinical practice. Thus, we aimed to identify the most frequent etiological agents responsible for vulvovaginal
allergies, the prevalent signs/symptoms, and the diagnostic tests applied in this clinical condition.
Methods Literature search was performed on PubMed, Scopus, Scielo, Web of Science, and EMBASE. The study protocol
was registered on PROSPERO (CRD42020167238). Studies were divided in two groups depending on allergen exposure
route. Due to a signifcant number of studies correlating allergy to Candida infection, subgroup analysis was included.
Results In direct exposure cases, Human Seminal Plasma was the most prevalent allergen, sensitizing 73% of afected women.
These women presented localized swelling and burning as prevalent symptoms, afecting 42/68 and 36/68 women, respectively. Cutaneous Prick tests were applied in 58/68 women, either alone or combined with IgE measurements. Regarding
cases of indirect/unidentifed exposure, house dust mites was the most prevalent allergen (54%), followed by pollen (44%).
Predominant symptoms were vulvar pruritus and burning, afecting 67/98 and 52/98 women. Skin prick test was the most
prevalent diagnostic method used among diferent studies. Hypersensitivity toward Candida antigen was present in only half
(163/323) of women presenting concomitant allergy and Candida infection.
Conclusion From the two types of allergen exposure that can cause vulvovaginal allergic responses, direct contact of the
antigen with the vulva and/or vagina was the most prevalent. Still, allergens can also sensitize the vaginal mucosa secondarily to other exposure route, specifcally aeroallergen

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

: Archives of Gynecology and Obstetrics., 2021

Deskripsi Fisik

Volume 306, issue 3, September 2022

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

NONE

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

online resource

Edisi

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Subjek

Kesehatan
Kebidanan
· Human seminal plasma
Aeroallergens, Skin prick test

Info Detail Spesifik

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Pernyataan Tanggungjawab

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