Electronic Resource

(J) Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy

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Purpose This study evaluated the potential viability of embryos with low mosaicism level (< 50%) by comparing the clinical
outcomes of single mosaic versus euploid blastocyst transfer. In addition, the live birth outcomes for various types of mosaicism
with respect to abnormalities in chromosome structure and content were analyzed.
Methods This study included patients who underwent in vitro fertilization with preimplantation genetic testing for aneuploidy
(PGT-A). The PGT-A cycles performed through next-generation sequencing with single euploid or mosaic embryo transfers
were included. We collected 299 frozen single embryo transfer cycles—216 single euploid and 83 mosaic—between July 2016
and July 2018. This study analyzed clinical outcomes, including fetal karyotyping by using amniocentesis, gestational age at
delivery, and live birth weight after single mosaic embryo transfer.
Results The average birth weight of infants in the euploid and mosaic blastocyst transfer groups was 3146.2 and 2997.7 g,
respectively. The karyotyping results of prenatal diagnosis in all pregnant women were normal. Our study indicated that mosaic
embryos can develop into euploid healthy infants with various levels or types of mosaicism. No significant difference was
observed between infants from euploid and mosaic blastocyst transfers.
Conclusion If patients have no euploid embryos, mosaic embryos can be transferred as they have potential for implantation and
development into euploid healthy infants. This study is invaluable for counseling clinical results after single mosaic embryo
transfers.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

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Penerbit

: Assisted Reproduction and Genetics., 2020

Deskripsi Fisik

Volume 37, issue 9, September 2020

Bahasa

English

ISBN/ISSN

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Klasifikasi

NONE

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

online resource

Edisi

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Subjek

Kesehatan
Kebidanan
Healthy live births from transfer of low-mosaicism

Info Detail Spesifik

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Pernyataan Tanggungjawab

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